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The error seems daunting but the main information to take away is: The server may be running out of resources, or the assembly may not be trusted with PERMISSION_SET = EXTERNAL_ACCESS or UNSAFE.
select name,is_trustworthy_on from sys.databases where name= 'SSISDB' ALTER DATABASE SSISDB SET TRUSTWORTHY ON; select name,is_trustworthy_on from sys.databases where name= 'SSISDB'
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